COX‐1, and not COX‐2 activity, regulates airway function: relevance to aspirin‐sensitive asthma
نویسندگان
چکیده
منابع مشابه
COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma
Cyclooxygenase (COX) -1 and COX-2 are expressed in airway cells, where their activities influence functions such as airway hyperreactivity. Clinical data show that mixed COX-1/COX-2 inhibitors such as aspirin, but not COX-2 selective inhibitors such as rofecoxib, induce bronchoconstriction and asthma in sensitive individuals. This anomaly has not yet been explained. Here, we have used tissue fr...
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1Division of Pulmonary and Critical Care Medicine, University of Washington, P.O. Box 356522, 1959 NE Pacific Street, Seattle, WA 98195-6522, USA 2Division of Pulmonary and Critical Care Medicine, Department of Medicine, and Cardiovascular Research Institute, University of California, San Francisco, CA 94143, USA 3Division of Anesthesiology, Pharmacology and Therapeutics, James Hogg iCAPTURE Ce...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2008
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fj.08-107979